What to look for in a fertility supplement

• Active 5-MTHF folate, not synthetic folic acid. Around one-third of UK adults carry an MTHFR gene variant that reduces their ability to convert synthetic folic acid into the active form. 5-MTHF skips the step.
• Active forms of B12 (methylcobalamin and adenosylcobalamin), not cyanocobalamin.
• A meaningful CoQ10 dose if you are 35+ or doing IVF. Most fertility research uses 200 to 600mg daily. Doses below 50mg are usually too low to matter.
• Vegan vitamin D3 from lichen, ideally 1000 to 4000 IU.
• Third-party batch testing with certificates available on request.
• No magnesium stearate, no titanium dioxide, no artificial colours.
• Vegan capsule shell, ideally delayed-release HPMC.

Best for 35+ or IVF prep

BioMirco Fertility Advance. The highest CoQ10 dose in the UK fertility category (300mg natural ubiquinone), both active forms of B12, 800µg of 5-MTHF folate, and a vegan vitamin D3 dose of 4000 IU. The doses are calibrated to what fertility nutritionists actually recommend for women 35+, not to NHS deficiency-prevention minimums.

See BioMirco Fertility Advance ›

Best for early TTC (under 35)

BioMirco Fertility Focus. Same active forms as Fertility Advance at moderated doses (200mg CoQ10, 533µg 5-MTHF, 2 capsules per day), designed to continue safely through the first trimester.

See BioMirco Fertility Focus ›

Best B Corp / minimalist option

Ovum Time to Conceive. A B Corp brand with a stripped-back 11-nutrient formula focused on high-dose actives: 800µg 5-MTHF folate, 200mg MicroActive sustained-release CoQ10, 4000 IU vitamin D, plus high-dose ALA (600mg) and NAC (600mg). Notable omissions: no iron, no iodine, no omega-3. Vegetarian rather than vegan.

Best mass-market option

Pregnacare Conception. The most affordable preconception multivitamin sold widely in UK supermarkets and pharmacies. Worth knowing what you are getting: synthetic folic acid (not 5-MTHF), cyanocobalamin B12 (not methylated), only 20mg of CoQ10, and animal-derived vitamin D3. Covers the NHS-recommended folate dose for women without MTHFR concerns who are early in trying.

Best premium all-in-one

Proceive Max Women. Strong active-form spec, 33 nutrients including choline and inositol, in a sweetened orange-flavour sachet (contains sucralose and steviol glycosides).

Best food-based option

Wild Nutrition Food-Grown Fertility. Uses yeast-bound naturally-occurring folate and B12 rather than chemically isolated forms. Includes cordyceps, NAC, and beetroot. Lowest mineral doses of the group and no CoQ10. Suitable for vegetarians but not vegans (dairy-cultured ingredients).

Best premium nutritionist-led

Zita West Vitafem. Strong all-rounder with Quatrefolic 5-MTHF folate, methylcobalamin B12, 40mg CoQ10, vegan capsules, and published Campden BRI third-party testing certificates.

Quick comparison